Helicobacter pylori (H. pylori) infection is a chronic infectious disease that is closely related to a variety of upper gastrointestinal diseases and some extragastric diseases. According to statistics from the National Cancer Center in March 2023, gastric cancer is one of the malignant tumors with a high incidence rate in our country. By location, non-cardia gastric cancer accounts for 85% to 90% of the total, 90% of which are related to H. pylori infection; according to histological classification, more than 80% are intestinal-type gastric cancer, and their occurrence and development are mostly in line with Correa’s theory.
How to reasonably and effectively manage H. pylori-positive subjects?
- For H. pylori-positive subjects who are ≥40 years old, have gastrointestinal symptoms, have other risk factors for gastric cancer, and need to take antithrombotic drugs, NSAIDs, and glucocorticoids for a long time, it is recommended to eradicate treatment and refer to a specialist for gastroscopy, etc. Inspection assessment and intervention.
- The risk of adverse drug reactions increases in the elderly. Therefore, whether to eradicate H. pylori in elderly patients should be evaluated comprehensively with benefits and risks, and individualized treatment should be carried out.
- “Family-based prevention and control of H. pylori infection” is an important strategy to prevent H. pylori infection and transmission. For H. pylori-positive subjects, adult members of their families need to be screened and treated for H. pylori infection.
- Antibiotic resistance and medication compliance are closely related to the effectiveness of H. pylori eradication. It is important to standardize eradication treatment and management, and the importance of improving the eradication rate of the first treatment must be emphasized.
- For those who turn negative in the re-examination 4-6 weeks after the end of H. pylori eradication treatment and those who screen negative for H. pylori, it is recommended that the interval for subsequent re-examinations be determined based on individual circumstances.
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Post time: Nov-20-2024